An approach based on diffusion to study ligand-macromolecule interaction.

A new approach has been developed to study binding of a ligand to a macromolecule based on the diffusion process. In terms of the Fick's first law, the concentration of free ligand in the presence of a protein can be determined by the measurement of those ligands which are diffused out. This method is applied to the study of binding of methyl-orange to lysozyme in phosphate buffer of pH 6.2, at...

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An Interaction-Based Approach to Semantic Alignment

We tackle the problem of semantic heterogeneity in the context of agent communication and argue that solutions based solely on ontologies and ontology matching do not capture adequately the richness of semantics as it arises in dynamic and open multiagent systems. Current solutions to the semantic heterogeneity problem in distributed systems usually do not address the contextual nuances of the ...

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An Interaction-Based Approach to Semantic Alignment

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An interaction-based approach to semantic alignment

We tackle the problem of semantic heterogeneity in the context of agent communication and argue that solutions based solely on ontologies and ontology matching do not capture adequately the richness of semantics as it arises in dynamic and open multiagent systems. Current solutions to the semantic heterogeneity problem in distributed systems usually do not address the contextual nuances of the ...

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An approach based on diffusion to study ligand-macromolecule interaction.

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